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For example, studies are underway to differentiate ESCs in to tissue specific CMs and to eradicate their immature properties that distinguish them from adult CMs.
Besides becoming an important alternative to organ transplants, ESCs are also being used in field of toxicology and as cellular screens to uncover new chemical entities (NCEs) that can be developed as small molecule drugs.
Only embryonic stem cells of the morula are totipotent: able to develop into any type of cell, including those of the placenta.
Studies have shown that cardiomyocytes derived from ESCs are validated in vitro models to test drug responses and predict toxicity profiles.
ESC-derived hepatocytes are also useful models that could be used in the preclinical stages of drug discovery.
Some of the cell types that have or are currently being developed include cardiomyocytes (CM), neurons, hepatocytes, bone marrow cells, islet cells and endothelial cells.
However, the derivation of such cell types from ESCs is not without obstacles, therefore current research is focused on overcoming these barriers.
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Under defined conditions, embryonic stem cells are capable of propagating indefinitely in an undifferentiated state.
Conditions must either prevent the cells from clumping, or maintain an environment that supports an unspecialized state.
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