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Although a previous study suggested ], this study is the first to evaluate cyclosporine pharmacokinetics in ECMO patients.
Data on vancomycin concentrations reported in ECMO are controversial.
In agreement with our observation, Mehta observed that vancomycin concentrations decreased by 36% when the drug was introduced in a new circuit while it decreased by only 11% when introduced in a circuit which had been running for five days .
Differences between experiment and control polypropylene tube propofol concentrations were statistically significant ( = 0.01 versus polypropylene control).
The cyclosporine concentration remained stable in the circuit for the first 5 hours, then decreased to 78% and 73% of the baseline value after 24 hours and 48 hours, respectively (Oxygen exposure and contact with PVC tubing resulted in 70% and 85% loss of propofol after 45 minutes, respectively.
Alternatively, propofol concentration decreased rapidly in the ECMO circuit, 70% of its baseline concentration being lost only 30 minutes after introduction of the drug into the circuit (Figure ).
After 5 hours, only 11% of the initial propofol concentration remained and the fraction remaining beyond 24 hours was negligible.
Alternatively, heating the polypropylene tube to 37°C had no effect on propofol concentration (Figure ECMO circuits primed with whole human blood, while cyclosporine concentration decreased slowly and moderately and vancomycin concentration remained unchanged.
Furthermore, we demonstrated that oxygen exposure and contact with PVC tubing were major factors leading to propofol degradation in ECMO circuits.
To determine spontaneous drug degradation, blood containing identical concentrations of the drugs studied was kept in polypropylene tubes under agitation at 25°C for the same time before measurements.
Propofol and midazolam concentrations were measured using high performance liquid chromatography with an ultra-violet detector (Waters, Milford, MA, USA).
Inadequate concentrations of antibacterial agents can lead to treatment failure that might compromise the outcomes of critically ill patients.Tags: Adult Dating, affair dating, sex dating