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Adhesion molecules and ligands promote cell-cell attachment and invasion, while proteases digest extracellular matrix (ECM) ahead of the invading embryo.
The invading cells of the embryo, called trophoblasts, invade in a fashion not unlike cancer cells, however, because of the extensive signaling mechanisms that exist between maternal and embryonic cells, uncontrolled spread and immunologic rejection are avoided.
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Animal models have shown a remarkable dissimilarity in implantation strategies, even when relatively closely related species are compared.
However, with the development of modern molecular biology techniques and with the use of the donor egg model from assisted reproductive technologies (ART), we are now gaining increasing knowledge about implantation, especially at the biochemical level.
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